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20 November 2008

BioBricks Foundation Release Wave of RFCs

The BioBricks Foundation (BBF) is dedicated to promoting and protecting the open development, sharing, and reuse of BioBrickā„¢ standard biological parts. The BBF is a not-for-profit organization founded by engineers and scientists from MIT, Harvard, and UCSF with significant experience in both non-profit and commercial biotechnology research. Taking inspiration from the Internet Engineering Task Force, the BBF is implementing a Request for Comments process. A Request for Comments, abbreviated RFC, is a short document that is intended for review by the rest of the community.

The UK Synthetic Biology Standards Network is co-ordinating the UK's interaction with the BBF and the definition of RFCs.

An RFC may:
* propose a standard of some sort (i.e. Tom Knight's 2003 BioBrick physical assembly standard or the Freiburg protein fusion assembly standard);
* describe best practices or protocols (i.e. a protocol for assembling two parts);
* provide information (i.e. a description of how to design transcriptional terminators);
* simply comment, extend, or replace an earlier RFC.

RFC's are static documents or digital objects like video's intended to get an idea, proposed standard, or method out to the rest of the community for comment. RFC's are numbered, for ease of referencing, and the numbers are assigned by the BBF.

Instructions for requesting a BBF RFC number, preparing an RFC, and submitting an RFC to the BBF are described in BBF RFC 0.

The complete list of all assigned RFC numbers and RFC documents (for those submitted) is listed below.

* BBF RFC 0: Instructions to BBF RFC Authors
* BBF RFC 1: Definition of the nature of a part
* BBF RFC 2: The information stored with a with a part
* BBF RFC 3: Restriction sites for the construction of fusion proteins
* BBF RFC 4: Synthetic Biology Diagram Standard
* BBF RFC 5: BioBrick Placeholders
* BBF RFC 6: Synthetic Terminators for Transcription Attenuation
* BBF RFC 7: Original Biobrick distribution
This is the data sheet accompanying the first public Biobrick distribution
* BBF RFC 8: Early Biobrick standard design
Early description of a (now defunct) Biobrick standard
* BBF RFC 9: Idempotent vector design for the standard assembly of Biobricks
Initial detailed motivation and definition of the Biobrick standard
* BBF RFC10: Draft standard for Biobrick biological parts
Formal description of the initial Biobrick standard
* BBF RFC 11: Biobrick assembly standard modifications
Proposed modification of enzymes to facilitate protein fusions (SpeI/NheI replaces XbaI/SpeI)
BBF RFC12: Draft Biobrick BB-2 standard for biological parts
Formal description of the Biobrick BB-2 standard

(Note: Much of the content on this page is sourced from OWW)